Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 177-241)

Specifications

Catalog number

PKSH032941-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neuregulin-1 (heregulin-1; NRG1) is a member of neuregulin family; which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I; type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors; concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Abbreviation

Pro-Neuregulin-1; NRG1 β1

Synonyms

EGF; GGF; HGL; HRG1-beta 1; HRGA; NDF; NRG1; NRG1-beta 1; Neuregulin-1 beta 1; Pro-neuregulin-1; SMDF

UniProt

Q02297

Accession Number

Q02297-6

Expression System

E.coli

Tag

None

Sequence

Ser177-Glu241

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

7.5 kDa

Observed Molecular Weight

8-10 kDa

Species

Human