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Product details

Recombinant Human PCSK9 Protein (His Tag)

Catalog number PKSH032944-01

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Price for PKSH032944-01

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Size / count 10 µg

Specifications

Catalog number
PKSH032944-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) ; and play a role in the neural development.
Abbreviation
PCSK9
Synonyms
NARC-1; NARC1; Neural Apoptosis-Regulated Convertase 1; PC9; PCSK9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9
UniProt
Q8NBP7
Accession Number
Q8NBP7
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gln31-Gln692 (Val474Ile, Gly670Glu)
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
13.77&58.2 kDa
Observed Molecular Weight
19&60 kDa
Formulation
24
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human PCSK9 Protein (His Tag)?

The catalog number for Recombinant Human PCSK9 Protein (His Tag) is PKSH032944.

What sizes are available for Recombinant Human PCSK9 Protein (His Tag)?

Recombinant Human PCSK9 Protein (His Tag) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human PCSK9 Protein (His Tag) come in?

Recombinant Human PCSK9 Protein (His Tag) is available in 2 different pack sizes.

Is Recombinant Human PCSK9 Protein (His Tag) in stock?

Recombinant Human PCSK9 Protein (His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human PCSK9 Protein (His Tag)?

Recombinant Human PCSK9 Protein (His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human PCSK9 Protein (His Tag)?

Estimated delivery time for Recombinant Human PCSK9 Protein (His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human PCSK9 Protein (His Tag)?

The safety data sheet for Recombinant Human PCSK9 Protein (His Tag) is available here: https://789.bio/eb/zXPmn1.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

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