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Product details

Recombinant Human PCSK9 Protein (AVI Tag)

Catalog number PKSH032946-01

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Price for PKSH032946-01

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Size / count 20 µg

Specifications

Catalog number
PKSH032946-01
Size / count
20 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) ; and play a role in the neural development.
Abbreviation
PCSK9
Synonyms
NARC-1; NARC1; Neural Apoptosis-Regulated Convertase 1; PC9; PCSK9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9
UniProt
Q8NBP7
Accession Number
Q8NBP7
Expression System
HEK293 Cells
Conjugation
Biotinylated
Tag
C-Avi
Sequence
Gln31-Gln692 (Val474Ile, Gly670Glu)
Applications
ELISA
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Immobilized Human LDLR-His (Cat: PKSH033435) at 10μg/ml (100 μl/well) can bind Human PCSK9-BiotinylatedAVI. The ED50 of Human PCSK9-BiotinylatedAVI is 126.41ug/ml.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
14&59 kDa
Observed Molecular Weight
19&65 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human PCSK9 Protein (AVI Tag)?

The catalog number for Recombinant Human PCSK9 Protein (AVI Tag) is PKSH032946.

What sizes are available for Recombinant Human PCSK9 Protein (AVI Tag)?

Recombinant Human PCSK9 Protein (AVI Tag) is available in the following size(s): 20 µg, 100 µg.

How many pack sizes does Recombinant Human PCSK9 Protein (AVI Tag) come in?

Recombinant Human PCSK9 Protein (AVI Tag) is available in 2 different pack sizes.

Is Recombinant Human PCSK9 Protein (AVI Tag) in stock?

Recombinant Human PCSK9 Protein (AVI Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human PCSK9 Protein (AVI Tag)?

Recombinant Human PCSK9 Protein (AVI Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human PCSK9 Protein (AVI Tag)?

Estimated delivery time for Recombinant Human PCSK9 Protein (AVI Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human PCSK9 Protein (AVI Tag)?

The safety data sheet for Recombinant Human PCSK9 Protein (AVI Tag) is available here: https://789.bio/eb/uT84yT.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

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