Recombinant Human PDIA6 Protein (His Tag)

Specifications

Catalog number

PKSH032958-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI) . PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1. PDIA6 also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.

Abbreviation

PDIA6

Synonyms

ER Protein 5; ERP5; ERp5; Endoplasmic Reticulum Protein 5; P5; PDIA6; Protein Disulfide Isomerase P5; Protein Disulfide-Isomerase A6; TXNDC7; Thioredoxin Domain-Containing Protein 7

UniProt

Q15084

Accession Number

Q15084

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu20-Leu440

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

47.2 kDa

Observed Molecular Weight

52 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.

Species

Human