Recombinant Human PTPN6/SH-PTP1 Protein (His Tag)

Specifications

Catalog number

PKSH032975-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors.

Abbreviation

PTPN6; SH-PTP1

Synonyms

HCP; Hematopoietic Cell Protein-Tyrosine Phosphatase; PTP-1C; PTP1C; PTPN6; Protein-Tyrosine Phosphatase 1C; Protein-Tyrosine Phosphatase SHP-1; SH-PTP1; Tyrosine-Protein Phosphatase Non-Receptor Type 6

UniProt

P29350

Accession Number

AAH02523.1

Expression System

E.coli

Tag

C-His

Sequence

Lys243-Ile541

Field of Research

Cell Biology, Signal Transduction, Cancer, Developmental Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

35.4 kDa

Observed Molecular Weight

34 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 2mM β-ME, 1mM EDTA, 1mM DTT, 20% Glycerol, pH 7.5.

Species

Human