Recombinant Human RARRES2/TIG2 Protein (His Tag)

Specifications

Catalog number

PKSH032994-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Retinoic acid receptor responder protein 2 (RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thought to act as a cell surface receptor, found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. RARRES2 is inhibited in psoriatic lesions, it is activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Abbreviation

RARRES2; TIG2

Synonyms

Chemerin; RAR-responsive protein TIG2; RARRES2; Retinoic acid receptor responder protein 2; TIG2; Tazarotene-induced gene 2 protein

UniProt

Q99969

Accession Number

Q99969

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu21-Ser157

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.9 kDa

Observed Molecular Weight

16-20 kDa

Species

Human