Recombinant Human S100A8 Protein (His Tag)

Specifications

Catalog number

PKSH033008-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Protein S100-A8 (also MRP8 and calgranulin A) is a calcium- and zinc-binding protein.It plays a prominent role in the regulation of inflammatory processes and immune response. S100A8 can induce neutrophil chemotaxis and adhesion. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. It can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Abbreviation

S100A8

Synonyms

60B8AG; CAGA; CFAG; CGLA; CP-10; Calgranulin-A; Cystic fibrosis antigen; L1Ag; Leukocyte L1 complex light chain; MA387; MIF; MRP-8; MRP8; NIF; P8; Protein S100-A8; S100A8

UniProt

P05109

Accession Number

P05109

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Glu93

Field of Research

Cell biology; Neuroscience; Cancer; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

11.7 kDa

Observed Molecular Weight

13 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 150mM NaCl, 20% Glycerol, 2mM EDTA, 0.05% Tween 80, pH8.5

Species

Human