Recombinant Human Sedoheptulokinase/SHPK Protein (His Tag)

Specifications

Catalog number

PKSH033014-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very weakly expressed in lung and brain. SHPK catalyzes the chemical reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphatecan, It can transform sedoheptulose to sedoheptulose 7-phosphate in the condition of ATP, and acts as a modulator of macrophage activation through control of glucose metabolism. In addition, It also can be down-regulated by LPS.

Abbreviation

Sedoheptulokinase; SHPK

Synonyms

CARKL; Carbohydrate kinase-like protein; SHK; SHPK; Sedoheptulokinase

UniProt

Q9UHJ6

Accession Number

AAH20543.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ser478

Field of Research

Signal Transduction; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

52.5 kDa

Observed Molecular Weight

53 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 3mM DTT, pH7.4.

Species

Human