Recombinant Human Semaphorin 4D/SEMA4D Protein (Fc Tag)

Specifications

Catalog number

PKSH033023-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Semaphorin-4D is also known as A8; BB18; GR3; CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain; 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells; regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/PYK2; which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.

Abbreviation

SEMA4D; CD100

Synonyms

A8; BB18; C9orf164; CD100; GR3; M-sema-G; SEMAJ; Semaphorin-4D; coll-4

UniProt

Q92854

Accession Number

AAH54500.1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Met22-Arg734

Field of Research

Neuroscience; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

106.4 kDa

Observed Molecular Weight

130-170 kDa

Species

Human