Recombinant Human SENP7 Protein

Specifications

Catalog number

PKSH033027-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.

Abbreviation

SENP7

Synonyms

KIAA1707; SENP7; SSP2; SUMO-1-Specific Protease 2; SUSP2; Sentrin-Specific Protease 7; Sentrin/SUMO-Specific Protease SENP7

UniProt

Q9BQF6

Accession Number

Q9BQF6

Expression System

E.coli

Tag

None

Sequence

Met695-Ala864

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

19.8 kDa

Observed Molecular Weight

22 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4.

Species

Human