Recombinant Human APCS/SAP Protein (His Tag)

Specifications

Catalog number

PKSH033050-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serum Amyoid P Component (SAP) is a monomeric 25 kDa secreted serum glycoprotein that belongs to the pentraxins family. The members of pentaxin superfamily be characterised by calcium dependent ligand binding and distinctive flattened β-jellyroll structure similar to that of the legume lectins. SAP is a non-fibrillar component; it can interact with DNA and histones. It regulates the solubility of amyloid fibrils and protects them from degradation by proteolytic enzymes and phagocytic cells. SAP scavenge nuclear material released from damaged circulating cells. It has been proposed that SAP may function as an opsonin for a variety of ligands including autoantigens; apoptotic cells; chromatin and micro-organisms.

Abbreviation

APCS; SAP

Synonyms

9.5S Alpha-1-Glycoprotein; APCS; PT; SAP; STX2; Serum Amyloid P-Component

UniProt

P02743

Accession Number

P02743

Expression System

HEK293 Cells

Tag

C-His

Sequence

His20-Val223

Field of Research

Cardiovascular; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.2 kDa

Observed Molecular Weight

30 kDa

Species

Human