Recombinant Human SLAMF6/Ly108 Protein (aa 22-225, Fc Tag)

Specifications

Catalog number

PKSH033063-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLAM Family Member 6 (SLAMF6) is a single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain; a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain; with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and; upon phosphorylation; with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells; NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

Abbreviation

SLAMF6; Ly108

Synonyms

Activating NK Receptor; CD352; KALI; Ly108; NK-T-B-Antigen; NTB-A; NTBA; SF2000; SLAM Family Member 6; SLAMF6

UniProt

Q96DU3

Accession Number

Q96DU3

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln22-Lys225

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

49.6 kDa

Observed Molecular Weight

55-65 kDa

Species

Human