Recombinant Human SOD2/Mn-SOD Protein (His Tag)

Specifications

Catalog number

PKSH033072-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6) ; idiopathic cardiomyopathy (IDC) ; sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.

Abbreviation

SOD2; Mn-SOD

Synonyms

SOD2; Superoxide Dismutase [Mn] Mitochondrial

UniProt

P04179

Accession Number

P04179

Expression System

E.coli

Tag

N-His

Sequence

Lys25-Lys222

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

23.7 kDa

Observed Molecular Weight

25 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 50% Glycerol, pH 8.0.

Species

Human