Recombinant Human Spondin 2/SPON2 Protein (His Tag)

Specifications

Catalog number

PKSH033076-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Spondin-2, also referred to as mindin, belongs to the F-spondin family of secreted extracellular matrix proteins. Spondins are characterised by the presence of F-spondin domains 1 and 2 (FS1 and FS2) at the N-terminus and a thrombospondin-type 1 repeat (TSR1) domain at the C-terminus. Spondin-2 functions as a pattern-recognition molecule for bacterial and viral pathogens and as an integrin ligand for inflammatory cell recruitment and T cell priming. In addition to its roles in promoting neuron outgrowth and inhibiting both cancer and angiogenesis, Spondin-2 plays an important role in the initiation of the immune response and is involved in inflammatory processes.

Abbreviation

Spondin 2; SPON2

Synonyms

DIL-1; Differentially expressed in cancerous and non-cancerous lung cells 1; Mindin; SPON2; Spondin-2

UniProt

Q9BUD6

Accession Number

AAH02707.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln27-Val331

Field of Research

Signal Transduction; Neuroscience; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

34.4 kDa

Observed Molecular Weight

38-42 kDa

Species

Human