Recombinant Human STMN1 Protein (His Tag)

Specifications

Catalog number

PKSH033079-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Stathmin (STMN1) is a ubiquitous cytosolic phosphoprotein which belongs to the Stathmin family. STMN1 is expressed in many tissues, with the highest expression in the brain, spinal cord, and cerebellum. It can also be expressed in the colon, ovary, placenta, uterus, and trachea. STMN1 participates in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is involved in the control of the learned and innate fear. STMN1 is an intracellular relay integrating regulatory signals of the cellular environment and as an Oncoprotein in regulation of the cell cycle. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Mutation in STMN1 effects cell homeostasis that may lead to tumorigenicity.

Abbreviation

STMN1

Synonyms

C1orf215; LAP18; Leukemia-Associated Phosphoprotein p18; Metablastin; OP18; Oncoprotein 18; Op18; Phosphoprotein p19; Prosolin; Protein Pr22; STMN1; Stathmin; pp17; pp19

UniProt

P16949

Accession Number

P16949

Expression System

E.coli

Tag

C-His

Sequence

Ala2-Asp149

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.4 kDa

Observed Molecular Weight

20 kDa

Species

Human