Recombinant Human Testin/TES Protein (His Tag)

Specifications

Catalog number

PKSH033102-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Testin belongs to the prickle/espinas/testin family. Testin contains three LIM zinc-binding domains and one PET domain, TES as a scaffold protein that may have a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. In addition, TES can also as a tumor suppressor, inhibits tumor cell growth, regulate the cell proliferation.TES interacts with many cytoskeletal proteins, such as Zyxin, Mena, Actin, Talin and VASP. The ability of TES to associate with alpha-actin, Zyxin and paxillin is dependent on the conformational state of the molecule.

Abbreviation

Testin; TES

Synonyms

TES; TESS; Testin

UniProt

Q9UGI8

Accession Number

Q9UGI8

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Ser421

Field of Research

Signal Transduction; Cancer; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

49.1 kDa

Observed Molecular Weight

50 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 1mM DTT, 10% Glycerol, pH 7.5.

Species

Human