Recombinant Human Thrombopoietin/TPO Protein (His Tag)

Specifications

Catalog number

PKSH033110-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Abbreviation

Thrombopoietin; TPO

Synonyms

C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin

UniProt

P40225

Accession Number

P40225

Expression System

HEK293 Cells

Tag

N-His & C-His

Sequence

Ser22-Gly353

Field of Research

Cell biology; Cardiovascular; Cancer; Stem cells

Endotoxin

< 0.01 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.3 kDa

Observed Molecular Weight

70-90 kDa

Species

Human