Recombinant Human TIMP2/TIMP-2 Protein (His Tag)

Specifications

Catalog number

PKSH033118-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs) . There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.

Abbreviation

TIMP2; TIMP-2

Synonyms

CSC-21K; DDC8; Metalloproteinase Inhibitor 2; Tissue Inhibitor of Metalloproteinases 2

UniProt

P16035

Accession Number

P16035

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys27-Pro220

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

22.8 kDa

Observed Molecular Weight

26 kDa

Species

Human