• Certified Lab Equipment & Reagents
  • Fast Dispatch on In-Stock Items
  • Expert Scientific Support

Product details

Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)

Catalog number PKSH033127-01

Selecting a variant updates its price, size and availability.

Price for PKSH033127-01

Sign In for Pricing

Size / count 10 µg

Specifications

Catalog number
PKSH033127-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
TNFRSF10B is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L) ; and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types; and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region; followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
Abbreviation
TRAIL R2; TNFRSF10B
Synonyms
CD262; DR5; Death Receptor 5; KILLER; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TNFRSF10B; TRAIL Receptor 2; TRAIL-R2; TRAILR2; TRICK2; Tumor Necrosis Factor Receptor Superfamily Member 10B; ZTNFR9
UniProt
O14763
Accession Number
O14763
Expression System
HEK293 Cells
Tag
C-Fc-His
Sequence
Ile56-Glu182
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
42.2 kDa
Observed Molecular Weight
49 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)?

The catalog number for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is PKSH033127.

What sizes are available for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)?

Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) come in?

Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is available in 2 different pack sizes.

Is Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) in stock?

Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)?

Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)?

Estimated delivery time for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag)?

The safety data sheet for Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) is available here: https://789.bio/eb/SyfXD8.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

You Might Also Like
CD7 (T3-3A1), CF405S conjugate, 0.1mg/mL
CD7 (T3-3A1), CF405S conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC040978-500
TGF-beta (1D11.16.8), CF647 conjugate, 0.1mg/mL
TGF-beta (1D11.16.8), CF647 conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC470977-100
Cytokeratin, LMW (AE-1), CF640R conjugate, 0.1mg/mL
Cytokeratin, LMW (AE-1), CF640R conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC400253-100
CD45RO (190-2F2.5), CF647 conjugate, 0.1mg/mL
CD45RO (190-2F2.5), CF647 conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC471081-100
HSP27 (G3.1), CF740 conjugate, 0.1mg/mL
HSP27 (G3.1), CF740 conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC740861-500
CD8 (C8/1035), CF568 conjugate, 0.1mg/mL
CD8 (C8/1035), CF568 conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC681035-500
CD31 / PECAM-1 (158-2B3), CF640R conjugate, 0.1mg/mL
CD31 / PECAM-1 (158-2B3), CF640R conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC400352-100
TNF alpha (J2D10), CF640R conjugate, 0.1mg/mL
TNF alpha (J2D10), CF640R conjugate, 0.1mg/mL
By Afraxis
Sign In for Pricing
Ref: BNC400994-100