Recombinant Human TRAIL R3/TNFRSF10C Protein (His Tag)

Specifications

Catalog number

PKSH033128-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

Abbreviation

TRAIL R3; TNFRSF10C

Synonyms

Antagonist Decoy Receptor for TRAIL/Apo-2L; DcR1; Decoy Receptor 1; Decoy TRAIL Receptor Without Death Domain; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand Receptor 3; TRAIL Receptor ; Tumor Necrosis Factor Receptor Superfamily Member 10C

UniProt

O14798

Accession Number

O14798

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala26-Ala221

Field of Research

Cell biology; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.8 kDa

Observed Molecular Weight

38-58 kDa

Species

Human