Recombinant Human TREML1/TLT-1 Protein (Fc Tag)

Specifications

Catalog number

PKSH033145-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide; a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain; and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs) . It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.

Abbreviation

TREML1; TLT-1

Synonyms

TLT-1; TLT1; TREML1; Trem-Like Transcript 1 Protein; Triggering Receptor Expressed on Myeloid Cells-Like Protein 1

UniProt

Q86YW5

Accession Number

Q86YW5

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln16-Pro162

Field of Research

Signal Transduction; Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.9 kDa

Observed Molecular Weight

50-60 kDa

Species

Human