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Product details

Recombinant Human TREM2 Protein (His Tag)

Catalog number PKSH033147-01

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Price for PKSH033147-01

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Size / count 10 µg

Specifications

Catalog number
PKSH033147-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage, and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. A positively charged lysine within the transmembrane segment allows association with the signal adapter protein, DAP12 and inhibition of macrophage activation. TREM2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes.It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria.
Abbreviation
TREM2
Synonyms
TREM-2; TREM2; Trem2a; Trem2b; Trem2c; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells 2
UniProt
Q9NZC2
Accession Number
Q9NZC2
Expression System
HEK293 Cells
Tag
C-His
Sequence
His19-Ser174
Field of Research
Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
18.3 kDa
Observed Molecular Weight
22-40 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human TREM2 Protein (His Tag)?

The catalog number for Recombinant Human TREM2 Protein (His Tag) is PKSH033147.

What sizes are available for Recombinant Human TREM2 Protein (His Tag)?

Recombinant Human TREM2 Protein (His Tag) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human TREM2 Protein (His Tag) come in?

Recombinant Human TREM2 Protein (His Tag) is available in 2 different pack sizes.

Is Recombinant Human TREM2 Protein (His Tag) in stock?

Recombinant Human TREM2 Protein (His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human TREM2 Protein (His Tag)?

Recombinant Human TREM2 Protein (His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human TREM2 Protein (His Tag)?

Estimated delivery time for Recombinant Human TREM2 Protein (His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human TREM2 Protein (His Tag)?

The safety data sheet for Recombinant Human TREM2 Protein (His Tag) is available here: https://789.bio/eb/nH4CSG.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

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