Recombinant Human UBE2B/HR6B Protein

Specifications

Catalog number

PKSH033179-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ubiquitin-Conjugating Enzyme E2 B (UBE2B) belongs to the ubiquitin-conjugating enzyme family. UBE2B can catalyze the covalent attachment of ubiquitin to other proteins; and is essential for the multi-ubiquitination and degradation of N-end rule substrates. UBE2B is indispensability for postreplication repair of UV-damaged DNA and may be involved in neurite outgrowth.Additionally; UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.

Abbreviation

UBE2B; HR6B

Synonyms

HR6B; RAD6 Homolog B; RAD6B; UBE2B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2 B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; hHR6B

UniProt

P63146

Accession Number

P63146

Expression System

E.coli

Tag

None

Sequence

Met 1-Ser152

Field of Research

Cell biology; Cancer; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

17.5 kDa

Observed Molecular Weight

18 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 10mM HEPES, pH 7.5.

Species

Human