Recombinant Human UBE2B/HR6B Protein (His Tag)

Specifications

Catalog number

PKSH033180-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18; UBR2; and WAC. UBE2B is required for post-replicative DNA damage repair. Additional; UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.

Abbreviation

UBE2B; HR6B

Synonyms

HR6B; RAD6 Homolog B; RAD6B; UBE2B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2 B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; hHR6B

UniProt

P63146

Accession Number

P63146

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ser152

Field of Research

Cell biology; Cancer; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

18.3 kDa

Observed Molecular Weight

17 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human