Recombinant Human UBE2V2/DDVIT1 Protein (His Tag)

Specifications

Catalog number

PKSH033191-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Abbreviation

UBE2V2; DDVIT1

Synonyms

DDVit 1; EDAF-1; EDPF-1; Enterocyte Differentiation-Associated Factor 1; Enterocyte Differentiation-Promoting Factor 1; MMS2; MMS2 Homolog; UBE2V2; UEV2; Ubiquitin-Conjugating Enzyme E2 Variant 2; Vitamin D3-Inducible Protein

UniProt

Q15819

Accession Number

Q15819

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Asn145

Field of Research

Cell biology; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

18.5 kDa

Observed Molecular Weight

18 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mm HEPES,150mM NaCl, pH 7.0.

Species

Human