Recombinant Human VCP Protein (His Tag)

Specifications

Catalog number

PKSH033203-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.

Abbreviation

VCP

Synonyms

15S Mg (2+) -ATPase p97 Subunit; TER ATPase; Transitional Endoplasmic Reticulum ATPase; VCP; Valosin-Containing Protein

UniProt

P55072

Accession Number

P55072

Expression System

E.coli

Tag

C-His

Sequence

Ala2-Asn589

Field of Research

Signal Transduction; Neuroscience; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

66.3 kDa

Observed Molecular Weight

75 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, pH8.0.

Species

Human