Recombinant Human VSIG4 Protein (Fc Tag)

Specifications

Catalog number

PKSH033219-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a transmembrane protein contains a signal peptide, a V-type Ig-like domain, a C2-type Ig-like domain, several potential O-glycosylation sites, and an intracellular domain with 2 potential phosphorylation sites and is structurally related to the B7 family of immune regulatory proteins. This protein is also a receptor for the complement component 3 fragments C3b and iC3b.The main function is strong negative regulator of T-cell proliferation and IL2 production and it is also potent inhibitor of the alternative complement pathway convertases. It abundantly expressed in several fetal tissues such as adult tissues, highest expression in lung and placenta and it also expressed in resting macrophages.

Abbreviation

VSIG4

Synonyms

CRIg; Protein Z39Ig; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG

UniProt

Q9Y279

Accession Number

Q9Y279

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Arg20-Val284

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

56.3 kDa

Observed Molecular Weight

75 kDa

Species

Human