Recombinant Human ZBTB17/Miz-1 Protein (His Tag)

Specifications

Catalog number

PKSH033230-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific genes, it has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. ZBTB17 may has growth arrest activity, probably through inhibition of cell cycle progression. ZBTB17 required for early embryonic development during gastrulation. ZBTB17 induces cell arrest at G1, an effect mediated by its activation of the gene coding for P15INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to ZBTB17. Although the downregulation of ZBTB17 may contribute to Myc-induced cell transformation, the de-activation of ZBTB17 is absolutely essential for Myc-induced apoptosis.

Abbreviation

ZBTB17; Miz-1

Synonyms

MIZ1; Miz-1; Myc-Interacting Zinc Finger Protein 1; ZBTB17; ZNF151; ZNF60; Zinc Finger Protein 151; Zinc Finger Protein 60; Zinc Finger and BTB Domain-Containing Protein 17

UniProt

Q13105

Accession Number

Q13105

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Ala188

Field of Research

Cancer; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

22.3 kDa

Observed Molecular Weight

18-26 kDa

Species

Human