Recombinant Human β-Arrestin 1/ARRB1 Protein (His Tag)

Specifications

Catalog number

PKSH033262-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in regulating receptor-mediated immune functions. ARRB1 is involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6.

Abbreviation

Β-Arrestin 1; ARRB1

Synonyms

ARR1; ARRB1; Arrestin Beta-1; Beta-Arrestin-1

UniProt

P49407

Accession Number

P49407

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Arg418

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.1 kDa

Observed Molecular Weight

60 kDa

Species

Human