Recombinant Human β-Defensin 1/DEFB1 Protein

Specifications

Catalog number

PKSH033264-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis, with apparent gender-specific effects in human. β-defensin 1 may also play a role in the pathogenesis of severe sepsis. In addition, β-defensin 1 is associated with induction profiles in gingival keratinocytes.

Abbreviation

Β-Defensin 1; DEFB1

Synonyms

BD-1; BD1; Beta-Defensin 1; DEFB1; Defensin Beta 1; HBD1; hBD-1

UniProt

P60022

Accession Number

P60022

Expression System

E.coli

Tag

None

Sequence

Gly22-Lys68

Field of Research

Microbiology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

5.1 kDa

Observed Molecular Weight

6 kDa

Species

Human