Recombinant Human β-Defensin 4A/DEFB4A Protein

Specifications

Catalog number

PKSH033266-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4; , which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.

Abbreviation

Β-Defensin 4A; DEFB4A

Synonyms

BD-2; Beta 2; Beta-Defensin 2; Beta-Defensin 4A; DEFB102; DEFB2; DEFB4; DEFB4A; DEFB4B; Defensin; SAP1; Skin-Antimicrobial Peptide 1; hBD-2

UniProt

O15263

Accession Number

O15263

Expression System

E.coli

Tag

None

Sequence

Gly24-Pro64

Field of Research

Microbiology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

4.3 kDa

Observed Molecular Weight

9 kDa

Species

Human