Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag)

Specifications

Catalog number

PKSH033276-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fructose-1;6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.

Abbreviation

FBPase 1; FBP1

Synonyms

6-Bisphosphatase 1;6-Bisphosphate 1-Phosphohydrolase 1; D-Fructose-1; FBP; FBP1; FBPase 1; Fructose-1

UniProt

P09467

Accession Number

P09467

Expression System

E.coli

Tag

C-His

Sequence

Ala2-Gln338

Field of Research

Signal Transduction; Cancer; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

37.9 kDa

Observed Molecular Weight

38 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0.

Species

Human