Recombinant Human FBPase 1/FBP1 Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH033277-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fructose-1;6-bisphosphatase 1 (FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.

Abbreviation

FBPase 1; FBP1

Synonyms

6-bisphosphatase 1;6-bisphosphate 1-phosphohydrolase 1; D-fructose-1; FBP; FBPase 1; Fructose-1

UniProt

P09467

Accession Number

P09467

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala2-Gln338

Field of Research

Signal Transduction; Cancer; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

37.8 kDa

Observed Molecular Weight

35-38 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mMEDTA, 10% Glycerol, pH 8.0.

Species

Human