Recombinant Human Calumenin Protein (aa 20-315, His Tag)

Specifications

Catalog number

PKSH033293-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calumenin is a secreted calcium-binding protein that belongs to the CREC family. Calumenin contains six EF-hand domains and is expressed at high levels in the heart; placenta and skeletal muscle. Human Calumenin is synthesized as a 315 amino acid precursor that contains a 19 amino acid signal sequence; and a 296 amino acid mature chain. Calumenin localizes to the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) of mammalian tissues which plays a role in ER functions as protein folding and sorting. Calumenin is involved in the regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit γ-carboxylase GGCX.

Abbreviation

Calumenin

Synonyms

CALU; Calumenin; Crocalbin; IEF SSP 9302

UniProt

O43852

Accession Number

O43852

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys20-Phe315

Field of Research

Tags & Cell Markers, Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 82 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.0 kDa

Observed Molecular Weight

40-55 kDa

Species

Human