Recombinant Human Tetherin/BST2 Protein (His Tag)

Specifications

Catalog number

PKSH033296-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Bone Marrow Stromal Antigen 2 (BST2) is a single-pass type II membrane protein that belongs to the tetherin family. BST2 is predominantly expressed in the liver; lung; heart and placenta. BST2 is involved in the sorting of secreted proteins. BST2 is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. BST2 is initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu; it has also been shown to inhibit the release of other viruses such as retroviruses; filoviruses; arenaviruses; and herpes viruses. BST2 may play a role in B-cell activation in rheumatoid arthritis.

Abbreviation

Tetherin; BST2

Synonyms

BST-2; BST2; Bone Marrow Stromal Antigen 2; CD317; HM1.24 Antigen; Tetherin

UniProt

Q10589

Accession Number

Q10589

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asn49-Ser161

Field of Research

Signal Transduction; Tags & Cell Markers; Cardiovascular; epigenetics and nuclear signal; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.7 kDa

Observed Molecular Weight

23 kDa

Species

Human