Recombinant Human TEM8/ATR Protein (His Tag)

Specifications

Catalog number

PKSH033297-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton; it mediates adhesion of cells to type 1 collagen and gelatin; reorganization of the actin cytoskeleton and promotes cell spreading. It is also involved in the angiogenic response of cultured umbilical vein endothelial cells; up-regulated in cultured angiogenic umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) .

Abbreviation

TEM8; ATR

Synonyms

ANTXR1; ATR; Anthrax Toxin Receptor 1; TEM8; Tumor Endothelial Marker 8

UniProt

Q9H6X2

Accession Number

Q9H6X2-4

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu33-Lys321

Field of Research

Tags & Cell Markers, Microbiology, Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

33.6 kDa

Observed Molecular Weight

35-45 kDa

Species

Human