Recombinant Human GM2A Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH033306-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB) . HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

Abbreviation

GM2A

Synonyms

Cerebroside sulfate activator protein; GM2-AP; Ganglioside GM2 activator; SAP-3; Sphingolipid activator protein 3

UniProt

P17900

Accession Number

AAH09273.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser32-Ile193

Field of Research

Signal Transduction; Tags & Cell Markers; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.6 kDa

Observed Molecular Weight

19-22 kDa

Species

Human