Recombinant Human CFHR1 Protein (His Tag)

Specifications

Catalog number

PKSH033320-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Complement Factor H-Related 1 (CFHR1) is a 43 kDa secreted member of the factor H family of glycoproteins. The human Complement Factor H protein family consists of the complement and immune regulators factor H; the factor H-like protein 1 (FHL-1) and five factor H-related proteins (CFHR-1 to -5) . Members of the H-related protein family are exclusively composed of individually folded protein domains; termed short consensus repeats (SCRs) or complement control modules. FHR1 is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa) . Mature human FHR1 is 312 amino acids in length. It contains five; approximately 60 aa SCRs that basically constitute the entire molecule. FHR1 may play a role in complement regulation; lipid metabolism and lipoprotein complexes that bind PMNs to LPS.

Abbreviation

CFHR1

Synonyms

CFHL; CFHL1; CFHL1P; CFHR1; CFHR1P; Complement Factor H-Related Protein 1; FHR-1; FHR1; H Factor-Like Protein 1; H-Factor-Like 1; H36; HFL1; HFL2

UniProt

Q03591

Accession Number

Q03591

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu19-Arg330

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.8 kDa

Observed Molecular Weight

37-52 kDa

Species

Human