Recombinant Human CD98 Protein (His Tag)

Specifications

Catalog number

PKSH033338-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD98 is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2/MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney; placenta and testis and weakest level in thymus. It consists of an 85 kDa glycosylated type II transmembrane heavy chain and a 40-50 kDa non-glycosylated light chain with 12 transmembrane segments. The heavy chain (SLC3A2) pairs with one of several light chains (SLC7A5; 6; 7; 8; 10; or 11) and is required for the cell surface expression and amino acid transport function of the light chains. It is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. It also mediates integrin signaling; T cell costimulation; B cell proliferation; and viral fusion with cell membranes.

Abbreviation

CD98

Synonyms

4F2;4F2 Cell-Surface Antigen Heavy Chain;4F2 Heavy Chain Antigen;4F2HC;4F2hc;4T2HC; CD98; CD98HC; Lymphocyte Activation Antigen 4F2 Large Subunit; MDU1; NACAE; SLC3A2

UniProt

P08195

Accession Number

P08195

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg206-Ala630

Field of Research

Immunology, Signal Transduction, Stem Cells, Metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

47.9 kDa

Observed Molecular Weight

50-75 kDa

Species

Human