Recombinant Human RGMA Protein (E.coli, His Tag)

Specifications

Catalog number

PKSH033343-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Repulsive guidance molecule A (RGMA) is a cell membrane protein and belongs to the repulsive guidance molecule (RGM) family. It interacts with NEO1; BMP2 and BMP4. RGMA is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. This protein may also function as a tumor suppressor in some cancers.

Abbreviation

RGMA

Synonyms

RGM; RGM domain family member A; Repulsive guidance molecule A

Accession Number

AAI51133.1

Expression System

E.coli

Tag

N-His

Sequence

Pro169-Gly422

Field of Research

Neuroscience; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

29.8 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 50% Glycerol, 1mM DTT, 0.05% Tween 80, pH 7.8.

Species

Human