Recombinant Human LYPD3 Protein (His Tag)

Specifications

Catalog number

PKSH033352-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ly6/PLAUR domain containing3 (LYPD-3) is a GPI-linked protein. The structure of LYPD-3 is similar to the urokinasetype plasminogen activator receptor (uPAR) . LYPD-3 is a 6 -100 kDa molecule with variable cell type-specific N-O-linked glycosylation; mature human LYPD-3 contains two uPAR/Ly6 domains and a Ser/Thr/Pro-rich (STP) region includes a protease sensitive site . The interaction of LYPD-3 with Laminin 1 and 5 on neighboring cells promotes the adhesion; spreading; and migration of tumor cells. LYPD-3 additionally interacts with Galectin-3 and the anterior gradient proteins AG-2 and AG-3. LYPD-3 overexpression in non-small cell lung cancer is predictive of increased mortality.

Abbreviation

LYPD3

Synonyms

C4.4A; GPI-Anchored Metastasis-Associated Protein C4.4A Homolog; LYPD3; Ly6/PLAUR Domain-Containing Protein 3; MIG-C4; Matrigel-Induced Gene C4 Protein

Accession Number

O95274

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu31-His286

Field of Research

Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.9 kDa

Observed Molecular Weight

55-75 kDa

Species

Human