Recombinant Human SIRP gamma/CD172g Protein (Fc Tag)

Specifications

Catalog number

PKSH033353-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

Abbreviation

SIRP gamma; CD172g

Synonyms

CD172 Antigen-Like Family Member B; CD172g; SIRP-Beta-2; SIRP-Gamma; SIRP-b2; SIRPB2; SIRPG; Signal-Fegulatory Protein Beta-2; Signal-Regulatory Protein Gamma

UniProt

Q9P1W8

Accession Number

Q9P1W8

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Glu29-Pro360

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

63.9 kDa

Observed Molecular Weight

80 kDa

Species

Human