Recombinant Human SULT1A1 Protein (His Tag)

Specifications

Catalog number

PKSH033358-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sulfotransferase 1A1 (SULT1A1) is a cytosolic sulfotransferases that is expressed in the liver; lung; adrenal; brain; platelets; and skin. SULT1A1 is a phenol sulfotransferases with thermostable enzyme activity. SULT1A1 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines; phenolic drugs and neurotransmitters. It is responsible for the sulfonation and activation of minoxidil. SULT1A1 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Abbreviation

SULT1A1

Synonyms

Aryl sulfotransferase 1; HAST1/HAST2; OK/SW-cl.88; P-PST 1; Phenol Sulfotransferase 1; Phenol-Sulfating Phenol Sulfotransferase 1; ST1A1; ST1A3; STP; STP1; SULT1A1; Sulfotransferase 1A1; Thermostable Phenol Sulfotransferase; Ts-PST

UniProt

P50225

Accession Number

AAH00923.1

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Leu295

Field of Research

Signal Transduction, Cancer, Metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

35.6 kDa

Observed Molecular Weight

32 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 50mM Nacl, 0.05% Tween 80, pH7.8.

Species

Human