Recombinant Human Jagged 1/JAG1 Protein (Fc Tag)

Specifications

Catalog number

PKSH033359-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.

Abbreviation

Jagged 1; JAG1

Synonyms

AGS; AHD; AWS; HJ1; JAG1 and CD339; JAGL1; Jagged 1; Jagged-1; Protein jagged-1 I

Accession Number

P78504

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln34-Ser1046

Field of Research

Cardiovascular; Neuroscience; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

137.6 kDa

Observed Molecular Weight

140-200 kDa

Species

Human