Recombinant Human OLFM4 Protein (His Tag)

Specifications

Catalog number

PKSH033360-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Olfactomedin-4/OLFM4 is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development; it strongly expressed in the prostate; small intestine; colon and moderately expressed in the bone marrow and stomach. OLFM4 is an antiapoptotic factor that promotes tumor growth. It expressed at high levels in stomach cancer and colon cancer tissues. it promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines; OLFM4 inhibits cell growth and induces cell differentiation and apoptosis. Through interaction with cell surface lectins and cadherin; OLFM4 facilitates cell adhesion. It may play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Induction of OLFM4 in cancer cells was reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19.

Abbreviation

OLFM4

Synonyms

Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; GW112; OLFM4; OLM4; Olfactomedin-4; hGC-1; hOLfD

Accession Number

Q6UX06

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp21-Gln510

Field of Research

Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

56.9 kDa

Observed Molecular Weight

60-90 kDa

Species

Human