Recombinant Human ST6GAL1 Protein (His Tag)

Specifications

Catalog number

PKSH033362-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The ST6GAL1 gene encodes β-Galactosamide α-2;6-Sialyltransferase 1. It is a type II membrane protein and is localized to the trans-Golgi network. It catalyzes 2;6-sialylation of Galβ1;4-GlcNAc structures on N-glycans. ST6GAL1 is highly expressed in the liver and other tissues. ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity. The expression and activity of ST6GAL1 are associated with tumor metastasis in breast and colon cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum and may be used as a biomarker for hepatitis diseases.

Abbreviation

ST6GAL1

Synonyms

6-ST 1;6-Sialyltransferase 1; Alpha 2; B-Cell Antigen CD75; Beta-Galactoside Alpha-2; CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2; SIAT1; ST6GAL1; ST6Gal I; ST6GalI; Sialyltransferase 1

UniProt

P15907

Accession Number

P15907

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys27-Cys406

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.6 kDa

Observed Molecular Weight

41-60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Human