Recombinant Human Chymotrypsin C Protein (His Tag)

Specifications

Catalog number

PKSH033366-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chymotrypsin C (CTRC) is a member of the peptidase S1 family. CTRC is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. CTRC has broad substrate specificity; but prefers tocleave on the carboxyl side of hydrophobic residues. CTRC is expressed primarily in the pancreas; and is secreted into the digestive tract. CTRC plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. It has been proposed that CTRC is a key regulator of digestive zymogen activation and is a physiological coactivator of digestive carboxypeptidases proCPA1 and proCPA2. The mutation of CTRC gene encodes the digestive enzyme CTRC contribute to the development of pancreatitis.

Abbreviation

Chymotrypsin C

Synonyms

CLCR; CTRC; Caldecrin; Chymotrypsin-C

UniProt

Q99895

Accession Number

Q99895

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys17-Leu268

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

29.0 kDa

Observed Molecular Weight

33-40 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-Hcl, 150mM NaCl , pH7.5.

Species

Human