Recombinant Human FLRT2 Protein (His Tag)

Specifications

Catalog number

PKSH033372-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fibronectin Leucine Rich Transmembrane protein 2 (FLRT2) is a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins: FLRT1; FLRT2 and FLRT3; all contain 10 leucine-rich repeats (LRR) ; a type III fibronectin (FN) domain; followed by the transmembrane region; and a short cytoplasmic tail. FLRT proteins have dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling. The fibronectin domain of all three FLRTs can bind FGF receptors. This binding is thought to regulate FGF signaling during development. The LRR domains are responsible for both the localization of FLRTs in areas of cell contact and homotypic cell cell association. FLRT2 is expressed in a subset of the sclerotome; adjacent to the region that forms the syndetome; suggesting its involvement in the FGF signalling pathway.

Abbreviation

FLRT2

Synonyms

FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2; KIAA0405; Leucine-Rich Repeat Transmembrane Protein FLRT2

UniProt

O43155

Accession Number

O43155

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys36-Ser539

Field of Research

Signal Transduction; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

57.3 kDa

Observed Molecular Weight

75-85 kDa

Species

Human