Recombinant Human GPA33 Protein (His Tag)

Specifications

Catalog number

PKSH033373-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Glycoprotein A33 (GPA33) is a single-pass type I membrane protein; belongs to the CTX family of cell adhesion molecular within the immunoglobulin family; can be expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 consists of one Ig-like C2-type domain and one Ig-like V-type domain. The predicted mature protein includes a single transmembrane domain; a extracellular region and a intracellular tail. Intracellular traffic and recycling to the cell surface appear to play an important role in GPA33 function and to have an influence on its surface density superseding translation regulation. GPA33 has become a promising target of immunologic therapy strategies. GPA33 may also play a important role in cell-cell recognition and signaling.

Abbreviation

GPA33

Synonyms

Cell Surface A33 Antigen; GPA33; Glycoprotein A33

UniProt

Q99795

Accession Number

Q99795

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile22-Val235

Field of Research

Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.7 kDa

Observed Molecular Weight

34-37 kDa

Species

Human