Recombinant Human FOLR1 Protein (His Tag)

Specifications

Catalog number

PKSH033374-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Folate receptor alpha (FOLR) belongs to the folate receptor family; and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney; lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor; or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Abbreviation

FOLR1

Synonyms

Adult folate-binding protein; FBP; FOLR; FOLR1; FR-alpha; Folate Binding Protein; Folate receptor; Folate receptor 1; Folate receptor alpha; Ovarian tumor-associated antigen MOv18

Accession Number

P15328

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg25-Ser234

Field of Research

Tags & Cell Markers

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.7 kDa

Observed Molecular Weight

28-38 kDa

Species

Human